GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs9815354 | 1 | rs1613759 | chr3:41906183 | ULK4 | chr3:41288091-42003660:- | 0.64 | 9.91 | 9.53E-21 | Diastolic blood pressure |
| BLCA | cis | rs9815354 | 1 | rs1615243 | chr3:41965234 | ULK4 | chr3:41288091-42003660:- | -0.63 | -9.71 | 4.41E-20 | Diastolic blood pressure |
| BLCA | cis | rs9815354 | 1 | rs1615543 | chr3:41906404 | ULK4 | chr3:41288091-42003660:- | 0.64 | 9.91 | 9.53E-21 | Diastolic blood pressure |
| BLCA | cis | rs9815354 | 1 | rs1628874 | chr3:41955714 | ULK4 | chr3:41288091-42003660:- | -0.63 | -9.74 | 3.43E-20 | Diastolic blood pressure |
| BLCA | cis | rs9815354 | 1 | rs1629460 | chr3:41927449 | ULK4 | chr3:41288091-42003660:- | -0.63 | -9.83 | 1.72E-20 | Diastolic blood pressure |
| BLCA | cis | rs1633360 | 1 | rs1633360 | chr12:58108052 | TSFM | chr12:58176536-58191367:+ | 0.26 | 4.61 | 5.6E-6 | Rheumatoid arthritis |
| BLCA | cis | rs1499614 | 1 | rs1638731 | chr7:66144679 | CCT6P1 | chr7:65216092-65228661:+ | 0.38 | 4.99 | 9.26E-7 | Gout |
| BLCA | cis | rs2243480 | 1 | rs1638734 | chr7:66097539 | CCT6P1 | chr7:65216092-65228661:+ | 0.35 | 4.78 | 2.49E-6 | Diabetic kidney disease |
| BLCA | cis | rs798766 | 1 | rs1665362 | chr4:1726367 | FAM53A | chr4:1641609-1685854:- | -0.34 | -4.97 | 1.0E-6 | Urinary bladder cancer;Bladder cancer |
| BLCA | cis | rs798766 | 1 | rs1665364 | chr4:1727206 | FAM53A | chr4:1641609-1685854:- | 0.33 | 5.13 | 4.6E-7 | Urinary bladder cancer;Bladder cancer |
| BLCA | cis | rs798766 | 1 | rs1665366 | chr4:1728381 | FAM53A | chr4:1641609-1685854:- | 0.36 | 5.19 | 3.43E-7 | Urinary bladder cancer;Bladder cancer |
| BLCA | cis | rs2692194 | 1 | rs166868 | chr15:80014686 | MTHFS | chr15:80137320-80189370:- | -0.24 | -4.46 | 1.08E-5 | IgG glycosylation |
| BLCA | cis | rs853679 | 1 | rs1679709 | chr6:28228342 | ZNF389 | chr6:28129551-28137375:+ | 0.34 | 4.3 | 2.13E-5 | Depression |
| BLCA | cis | rs853679 | 1 | rs1679732 | chr6:28221264 | ZNF389 | chr6:28129551-28137375:+ | 0.33 | 4.24 | 2.83E-5 | Depression |
| BLCA | cis | rs344081 | 1 | rs16826864 | chr3:156580033 | LEKR1 | chr3:156544076-156763918:+ | -0.47 | -6.39 | 4.95E-10 | Bone mineral density |